Effect of nutmeg extract on the white adipose tissue (WAT) browning process of aging rats

The white adipose tissue (WAT) browning process has become one of the promising methods for managing obesity. During this process, WAT is transformed into brown-like tissue, which also known as beige tissue. can be activated by several inducers. One best candidates peroxisome proliferator-activated receptor γ (PPARγ) agonist. Nutmeg (Myristica fragrans Houtt) a natural PPARα/γ partial agonist that to contribute effect. This study aimed explore potential effect nutmeg seed extract (NuSE) on body weight reduction and uncoupling protein (UCP)1, UCP2, UCP3, gamma coactivator-1 PGC-1α levels in aging rats. Eight male Wistar rats (80 weeks old) were divided control treatment groups. Both groups fed standard diet, group was given 8.1 mg/kg weight/day NuSE via oral gavage 12 weeks. After weeks, UCP1, from both inguinal (iWAT) interscapular brown (BAT) examined. We observed administration no significant decreasement weights (p = 0.464), UCP1 0.686), UCP2 0.360), UCP3 0.076), 0.200).